Centuries ago, the ruthless feudal warlord Gengetsu Kibaoni was slain by the Igasaki Ninja clan, before discarding his humanity to become a Yokai. In his first attempt to rise again, Kibaoni was defeated and sealed by Yoshitaka Igasaki, a man known as the Last Ninja, but three generations later, Kibaoni is unsealed by his retainer Kyuemon Izayoi. As only members of Igasaki’s bloodline can stop the rampaging Yokai, Yoshitaka’s son Tsumuji Igasaki assembles the Ninningers, composed of his children Takaharu and Fuka and their cousins Yakumo Kato, Nagi Matsuo, and Kasumi Momochi, to master their clan’s Shuriken Ninja Arts and fight the Kibaoni Army Corps. The team is later joined by Kinji Takigawa, a Yokai Hunter from the United States who becomes Yoshitaka’s disciple after earning his trust.Also, according to their grandfather, one among them will be chosen to inherit the title of Last Ninja, and become the guardian of the Igasaki family’s ultimate treasure, the “End Shuriken”, which is also coveted by the Kibaoni Corps in their plan to revive their master and take over the world by fear.
战国时代── 以恐怖来统治天下 最凶最恶的武将“牙鬼幻月”。由“伊贺崎家”率领的一群忍者, 经过激烈的战斗，打倒了“牙鬼幻月”。 但“牙鬼幻月”却留下了不详的预言… “444年后, 我将变成妖怪复活再次以恐怖支配天下!”时光流逝── 末代忍者“伊贺崎好天”跟复活的妖怪“牙鬼幻月”决斗, 并成功将它封印。时光再次流逝 到了现代── “牙鬼幻月”的封印被解除, “牙鬼幻月”的怨念生出了一批妖怪，这些妖怪们组成“牙鬼军团”， 为了让“牙鬼幻月”完全复活，妖怪们到处搜集人们的恐惧心，开始向人们展开袭击!紧急时刻，出现了5个年轻人。 他们正是伊贺崎家的末裔, 也就是末代忍者・伊贺崎好天的孙子们!“当忍则忍，可不忍则不忍！” 三代同堂，用火热的“忍者心”（Nintality），以及各种异想天开的忍术来漂亮的击退妖怪！为了继承祖父的“末代忍者”这个封号, 也为了阻止妖怪军团让“牙鬼幻月”复活， 现在他们不仅不忍，还要大肆反击!